The term, “mindfulness” actually does not have an absolutely fixed definition in the research world. From a clinical point of view, however, the COAL state of being curious, open, accepting, and loving, offers a practical way to describe the key features of what “being mindful” entails. Investigations reveal that three pillars of mind training leads to this mindfulness state: focusing attention, opening awareness, and developing kind intention or compassion and caring. We will explore how this three pillar mind training leads to five physiological mechanisms of bodily health and an enhancement of neural integration in the brain. Three pillar mind training for traumatized individuals offers a strategy for developing the very aspects of neural integration that have been compromised in developmental trauma: Prefrontal cortex, hippocampus, corpus callosum and the overall connectome are the areas that grow with this therapeutic intervention.